Publications - Piao Lab

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Wang L, Pang K, Zhou L, Cebri疣-Silla A, Gonz疝ez-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, Garcia-Verdugo JM, Alvarez-Buylla A, Liu Z, Kriegstein AR. (2023). A cross-species proteomic map reveals neoteny of human synapse development. Nature. 2023 Oct;622(7981):112-119. doi: 10.1038/s41586-023-06542-2. PMID: 37704727 Jain S, Allen IA, Song D, Piao X. (2023). Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis. Front Pediatr. 2023;11:1277697. doi: 10.3389/fped.2023.1277697. PubMed PMID: 37915987; PubMed Central PMCID: PMC10616592 Jain S, Oltman S, Rogers E, Ryckman K, Petersen M, Baer RJ, Rand L, Piao X, Jelliffe-Pawlowski L. (2023). Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis. J Perinatol. 2023 Dec;43(12):1486-1493 doi: 10.1038/s41372-023-01820-3. Epub 2023 Nov 10. PMID: 37950045 Wilde C, Chaudhry PM, Luo R, Simon KU, Piao X, Liebscher I. (2023). Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6. Cells. 2023 Jun 5;12(11):1551. doi: 10.3390/cells12111551. PMID: 37296671 Li T, Luo R, Schmidt R, D'Alessandro N, Kishore P, Zhu B, Yu D, Piao X. (2023). GPR56 S4 variant is required for microglia-mediated synaptic pruning. Glia. 2023 Mar;71(3):560-570. doi: 10.1002/glia.24293. Epub 2022 Nov 6.PMID: 36336959 Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, Villeda SA, Piao X. (2022). Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Sci Adv. 2022 May 6;8(18):eabm2545. doi: 10.1126/sciadv.abm2545. Epub 2022 May 6.PMID: 35544642 Motavaf M, Piao X. (2021). Oligodendrocyte Development and Implication in Perinatal White Matter Injury. Front Cell Neurosci. 2021 Nov 4;15:764486. doi: 10.3389/fncel.2021.764486. eCollection 2021.PMID: 34803612 Hsiao CC, Kragten NAM, Piao X, Hamann J, van Gisbergen KPJM. (2021). The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo. Cells. 2021 Oct 6;10(10):2675. doi: 10.3390/cells10102675. PMID: 34685654 Karasek D, Baer RJ, McLemore MR, Bell AJ, Blebu BE, Casey JA, Coleman-Phox K, Costello JM, Felder JN, Flowers E, Fuchs JD, Gomez AM, Karvonen K, Kuppermann M, Liang L, McKenzie-Sampson S, McCulloch CE, Oltman SP, Pantell MS, Piao X, Prather AA, Schmidt RJ, Scott KA, Spellen S, Stookey JD, Tesfalul M, Rand L, Jelliffe-Pawlowski LL.(2021) CThe association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California. Lancet Reg Health Am. 2021 Oct;2:100027. doi: 10.1016/j.lana.2021.100027. Epub 2021 Jul 30. PMID: 34642685 Li T, Yu D, Oak HC, Zhu B, Wang L, Jiang X, Molday RS, Kriegstein A, Piao X. (2021). Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure. EMBO J. 2021 Sep 29:e107915. doi: 10.15252/embj.2021107915. Online ahead of print. PMID: 34585770 Popova G, Soliman SS, Kim CN, Keefe MG, Hennick KM, Jain S, Li T, Tejera D, Shin D, Chhun BB, McGinnis CS, Speir M, Gartner ZJ, Mehta SB, Haeussler M, Hengen KB, Ransohoff RR, Piao X, Nowakowski TJ. (2021). Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Cell Stem Cell. 2021 Sep 16:S1934-5909(21)00376-3. doi: 10.1016/j.stem.2021.08.015. Online ahead of print. PMID: 34536354 Jain S, Baer RJ, McCulloch CE, Rogers E, Rand L, Jelliffe-Pawlowski L, Piao X. (2021). Association of Maternal Immune Activation during Pregnancy and Neurologic Outcomes in Offspring. J Pediatr. 2021 May 7:S0022-3476(21)00421-2. doi: 10.1016/j.jpeds.2021.04.069. Online ahead of print. PMID: 33965413 Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke ML, Dzierzak E. (2021). Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood Adv. 2021 Feb 9;5(3):829-842. doi: 10.1182/bloodadvances.2020003693. PMID: 33560396
Yeung J, Adili R, Stringham EN, Luo R, Vizurraga A, Rosselli-Murai LK, Stoveken HM, Yu M, Piao X, Holinstat M, Tall GG. (2020). GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28275-28286. doi: 10.1073/pnas.2008921117. Epub 2020 Oct 23. PMID: 33097663 Chiou B, Gao C, Giera S, Folts CJ, Kishore P, Yu D, Oak HC, Jiang R, Piao X. (2020). Cell type-specific evaluation of ADGRG1/GPR56 function in developmental central nervous system myelination. Glia. 2021 Feb;69(2):413-423. doi: 10.1002/glia.23906. Epub 2020 Sep 9.PMID: 32902916 Li T, Chiou B, Gilman CK, Luo R, Koshi T, Yu D, Oak HC, Giera S, Johnson-Venkatesh E, Muthukumar AK, Stevens B, Umemori H, Piao X. (2020). A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding. EMBO J. 2020 Aug 17;39(16):e104136. doi: 10.15252/embj.2019104136. Epub 2020 May 25. PMID: 32452062
Zhu B, Luo R, Jin P, Li T, Oak HC, Giera S, Monk KR, Lak P, Shoichet BK, Piao X. (2019). GAIN domain-mediated cleavage is required for activation of G protein-coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist. J Biol Chem. doi: 10.1074/jbc.RA119.008234. Epub 2019 Oct 18. Cauley ES, Hamed A, Mohamed IN, Elseed M, Martinez S, Yahia A, Abozar F, Abubakr R, Koko M, Elsayed L, Piao X, Salih MA, Manzini MC. (2019). Overlap of polymicrogyria, hydrocephalus, and Joubert syndrome in a family with novel truncating mutations in ADGRG1/GPR56 and KIAA0556. Neurogenetics. doi: 10.1007/s10048-019-00577-2. Chen R, Piao X, Xiao M, Wang F, Liu L. (2019). Long noncoding RNAs interact with mRNAs: A new perspective on the mechanism of premature brain injury. Neurosci Lett. doi: 10.1016/j.neulet.2019.05.028. Folts CJ, Giera S, Li T, Piao X. (2019). Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases. Trends Pharmacol Sci. doi: 10.1016/j.tips.2019.02.003. Review. Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, Stevens B. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. (2019). Immunity. doi: 10.1016/j.immuni.2018.11.004. Morgan RK, Anderson GR, Arac D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Promel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. (2019). The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. doi: 10.1111/nyas.14094.
Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X. (2018). Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. eLife. doi: 10.7554/eLife.33385. Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR. (2018). GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine. 215(3):941-961 Olaniru OE, Pingitore A, Giera S, Piao X, Castanera Gonzalez R, Jones PM, Persaud SJ. (2018). The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve B- cell function. Cell Mol Life Sci. doi: 10.1007/s00018-018-2846-4.
Mehta P, Kuspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB. (2017). Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Muscle Nerve. doi: 10.1002/mus.25416. Mehta P, Piao X. (2017). Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development. Dev Dyn. doi: 10.1002/dvdy.24473. Review. Moreno M, Pedrosa L, Pare L, Pineda E, Bejarano L, Martinez J, Balasubramaniyan V, Ezhilarasan R,Kallarackal N, Kim SH, Wang J, Audia A, Conroy S, Marin M, Ribalta T, Pujol T, Herreros A,Tortosa A, Mira H, Alonso MM, Gomez-Manzano C, Graus F, Sulman EP, Piao X, Nakano I, Prat A, Bhat KP, de la Iglesia N. (2017). GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma. Cell Rep. doi: 10.1016/j.celrep.2017.10.083.
Mogha A, Harty BL, Carlin D, Joseph J, Sanchez NE, Suter U, Piao X, Cavalli V, Monk KR. (2016). Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. J Neurosci. 36(49):12351-12367. Mehta P, Piao X. (2016). Adhesion G-Protein Coupled Receptors and Extracellular Matrix Proteins: Roles in Myelination and Glial Cell Development. Dev Dyn. doi: 10.1002/dvdy.24473. [Epub ahead of print] Review. Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL. (2016). Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination. Handb Exp Pharmacol. 234:275-298. Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB. (2016). Novel Mutation in CNTNAP1 results in Congenital Hypomyelinating Neuropathy. Muscle Nerve. doi: 10.1002/mus.25416. [Epub ahead of print] Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. (2016). Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 91(6):1292-304. Langenhan T, Piao X, Monk KR. (2016). Adhesion G protein-coupled receptors in nervous system development and disease. Nat Rev Neurosci. 17(9): 550-61.
Chen P, Piao X, Bonaldo P. (2015). Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. Acta Neuropathologica 130, 605-618. Schöneberg T, Liebscher I, Luo R, Monk KR, Piao X. (2015). Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation. Journal of Receptors and Signal Transduction 35, 220-223. Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. (2015). High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem cell research 14, 307-322. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. (2015). International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors. Pharmacological reviews, 67(2), 338-367. Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR. (2015). The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron, 85(4), 755-769. Featured cover article. Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. (2015). The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nature communications, 6. Featured in the Washington University Record. Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. (2015). The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nature communications, 6.
Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. (2014). New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences, 1333(1), 43-64. White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. (2014). G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proceedings of the National Academy of Sciences, 111(44), 15756-15761. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. (2014). Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PloS ONE 9, e100043. Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Šestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. (2014). Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science, 343(6172), 764-768.
Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. (2013). G-protein coupled receptor 56 promotes myoblast fusion through serum response factorﾂ∥nd nuclear factor of activated T-cellﾂ‐mediated signalling but is not essential for muscle development in vivo. FEBS Journal, 280(23), 6097-6113. Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. (2013). GPR56 functions together with alpha3betable integrin in regulating cerebral cortical development. PLoS One, 8, e68781. Singer K, Luo R, Jeong SJ, Piao X. (2013). GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration. Molecular neurobiology, 47(1), 186-196.
Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. (2012). Dissecting signaling and functions of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences, 1276(1), 1-25. Jeong SJ, Luo R, Li S, Strokes N, Piao X. (2012) Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. Journal of Comparative Neurology 520, 2930-2940. Luo R, Jin Z, Deng Y, Strokes N, Piao X. (2012) Disease-Associated Mutations Prevent GPR56-Collagen III Interaction. PLoS One 7, e29818. Jeong SJ, Li S, Luo R, Strokes N, Piao X. (2012) Loss of Col3a1, the Gene for Ehlers-Danlos Syndrome Type IV, Results in Neocortical Dyslamination. PLoS One 7, e29767.
Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X. (2011) G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proceedings of the National Academy of Sciences 108, 12925-12930. Luo R, Yang HM, Jin Z, Halley DJ, Chang BS, MacPherson L, Brueton L, Piao X. (2011) A Novel GPR56 Mutation Causes Bilateral Frontoparietal Polymicrogyria. Pediatric neurology 45, 49-53.
Strokes N, Piao X. (2010) Adhesion-GPCRs in the CNS. Adv Exp Med Biol 706: 87-97. doi:10.1007/978-1-4419-7913-1_7
Koirala S, Jin Z, Piao X, Corfas G. (2009) GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci 29(23):7439-49. Jin Z, Luo R, Piao X. (2009) GPR56 and its related diseases. Progress in molecular biology and translational science 89, 1-13.
Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. (2008) GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci 28: 5817-26.
Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X. (2007) Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. Hum Mol Genet 16: 1972-85.
Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R, Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA. (2005) Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes. Ann Neurol 58: 680-7.
Piao X, Walsh CA. (2004) A novel signaling mechanism in brain development. Pediatric research 56. Chang BS, Piao X, Giannini C, Cascino GD, Scheffer I, Woods CG, Topcu M, Tezcan K, Bodell A, Leventer RJ, Barkovich AJ, Grant PE, Walsh CA. (2004) Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation. Neurology. 62(10):1722-8. Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Déscarie JC, Barkovich AJ, Walsh CA. (2004) G protein-coupled receptor-dependent development of human frontal cortex. Science 303, 2033-2036.
Chang BS, Piao X, Bodell A, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Grant PE, Barkovich AJ, Walsh CA. (2003) Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16. Ann Neurol 53: 596-606.
Piao X, Basel-Vanagaite L, Straussberg R, Grant PE, Pugh EW, Doheny K, Doan B, Hong SE, Shugart YY, Walsh CA. (2002) An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. Am J Hum Genet 70: 1028-33.
Bennett DC, Trayner ID, Piao X, Easty DJ, Klüppel M, Alexander WS, Wagner EF, Bernstein A. (1998) recessive spotting: a linked locus that interacts with W/Kit but is not allelic. Genes Cells. 3(4):235-44. Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A. (1996) Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A. 93(25):14665-9. Piao X, Bernstein A. (1996) A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells. Blood. 87(8):3117-23. Xu WM, Piao XH, Addy L, Jamal M, Minden MD, Messner HA. (1994) Minimal residual disease in bone marrow transplant recipients with chronic myeloid leukemia. Bone Marrow Transplant. 14(2):299-306. Piao X, Curtis JE, Minkin S, Minden MD, Bernstein A. (1994) Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia. Blood. 83(2):476-81. Yan MS, Xiue S, Wei LX, Piao XH. (1993) The preliminary observation on immunosuppressive effect of norcantharidin in mice. Immunopharmacol Immunotoxicol. 15(1):79-85. Bai Y, Piao XH, Luo QL, Mao BZ. (1990) Monoclonal antibody 55 (CD10) and complement used for purging autologous bone marrow in common acute lymphoblastic leukemia. Chin Med J (Engl). 103(5):385-90.